Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway
Identifieur interne : 000139 ( Main/Exploration ); précédent : 000138; suivant : 000140Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway
Auteurs : Zhiling Fu [République populaire de Chine] ; Ze Zhang [République populaire de Chine] ; Xiuying Wu [République populaire de Chine] ; Jin Zhang [République populaire de Chine]Source :
- BioMed Research International [ 2314-6133 ] ; 2020.
Abstract
Hydrogen-rich saline (HRS) has strong anti-inflammatory, antioxidative stress, and antiapoptotic properties. The study focused on the protection of HRS on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rat models and the relationship with autophagic regulation and mTOR/TFEB signaling pathway.
HRS attenuated LPS-induced ALI and apoptosis both in
The results confirmed the protection of HRS in LPS-induced ALI by regulating apoptosis through inhibiting the mTOR/TFEB signaling pathway.
Url:
DOI: 10.1155/2020/9121894
PubMed: 32071922
PubMed Central: 7011387
Affiliations:
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wicri:level="1"><nlm:aff id="I2">Department of Orthopedics, Shenyang 739 Hospital, No. 121 Yellow River North Street, Huanggu District, Shenyang, Liaoning Province 110004, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopedics, Shenyang 739 Hospital, No. 121 Yellow River North Street, Huanggu District, Shenyang, Liaoning Province 110004</wicri:regionArea><wicri:noRegion>Liaoning Province 110004</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Xiuying" sort="Wu, Xiuying" uniqKey="Wu X" first="Xiuying" last="Wu">Xiuying Wu</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province 110004, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province 110004</wicri:regionArea><wicri:noRegion>Liaoning Province 110004</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jin" sort="Zhang, Jin" uniqKey="Zhang J" first="Jin" last="Zhang">Jin Zhang</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province 110004, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province 110004</wicri:regionArea><wicri:noRegion>Liaoning Province 110004</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32071922</idno><idno type="pmc">7011387</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011387</idno><idno type="RBID">PMC:7011387</idno><idno type="doi">10.1155/2020/9121894</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000424</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000424</idno><idno type="wicri:Area/Pmc/Curation">000424</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000424</idno><idno type="wicri:Area/Pmc/Checkpoint">000130</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000130</idno><idno type="wicri:Area/Ncbi/Merge">000F40</idno><idno type="wicri:Area/Ncbi/Curation">000F40</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F40</idno><idno type="wicri:doubleKey">2314-6133:2020:Fu Z:hydrogen:rich:saline</idno><idno type="wicri:Area/Main/Merge">000139</idno><idno type="wicri:Area/Main/Curation">000139</idno><idno type="wicri:Area/Main/Exploration">000139</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway</title><author><name sortKey="Fu, Zhiling" sort="Fu, Zhiling" uniqKey="Fu Z" first="Zhiling" last="Fu">Zhiling Fu</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province 110004, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province 110004</wicri:regionArea><wicri:noRegion>Liaoning Province 110004</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Ze" sort="Zhang, Ze" uniqKey="Zhang Z" first="Ze" last="Zhang">Ze Zhang</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Orthopedics, Shenyang 739 Hospital, No. 121 Yellow River North Street, Huanggu District, Shenyang, Liaoning Province 110004, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopedics, Shenyang 739 Hospital, No. 121 Yellow River North Street, Huanggu District, Shenyang, Liaoning Province 110004</wicri:regionArea><wicri:noRegion>Liaoning Province 110004</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Xiuying" sort="Wu, Xiuying" uniqKey="Wu X" first="Xiuying" last="Wu">Xiuying Wu</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province 110004, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province 110004</wicri:regionArea><wicri:noRegion>Liaoning Province 110004</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jin" sort="Zhang, Jin" uniqKey="Zhang J" first="Jin" last="Zhang">Jin Zhang</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province 110004, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning Province 110004</wicri:regionArea><wicri:noRegion>Liaoning Province 110004</wicri:noRegion></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p> Hydrogen-rich saline (HRS) has strong anti-inflammatory, antioxidative stress, and antiapoptotic properties. The study focused on the protection of HRS on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rat models and the relationship with autophagic regulation and mTOR/TFEB signaling pathway. <italic>Material and Methods</italic>. The LPS-induced ALI rats' model was established. Pathohistological change in lung tissue was detected by hematoxylin-eosin staining. The inflammatory cytokines were examined by enzyme-linked immunosorbent assay (ELISA). The key apoptosis proteins and autophagy-relevant proteins were analyzed by western blotting. In vitro, HPMEC models of ALI were treated with LPS. The inflammatory cytokines were detected. Apoptosis rate was determined by flow cytometry. The autophagy and mTOR/TFEB signaling pathway-related proteins were detected by western blot and immunohistochemical staining. </p></sec><sec><title>Results</title><p> HRS attenuated LPS-induced ALI and apoptosis both in <italic>vivo</italic> and in <italic>vitro</italic>. HRS attenuated inflammatory response, inhibited apoptosis, induced and activated autophagy in LPS-induced ALI model, and downregulated mTOR/TFEB signaling pathway. The protection of HRS can be blocked by autophagy inhibitor. Moreover, mTOR activator reversed HRS protection and mTOR inhibitor enhanced HRS protection in LPS-induced model and HRS activated autophagy via mTOR/TFEB signaling pathway. </p></sec><sec><title>Conclusion</title><p> The results confirmed the protection of HRS in LPS-induced ALI by regulating apoptosis through inhibiting the mTOR/TFEB signaling pathway.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Perl, M" uniqKey="Perl M">M. Perl</name></author><author><name sortKey="Chung, C S" uniqKey="Chung C">C.-S. Chung</name></author><author><name sortKey="Perl, U" uniqKey="Perl U">U. Perl</name></author><author><name sortKey="Thakkar, R" uniqKey="Thakkar R">R. Thakkar</name></author><author><name sortKey="Lomas Neira, J" uniqKey="Lomas Neira J">J. Lomas-Neira</name></author><author><name sortKey="Ayala, A" uniqKey="Ayala A">A. Ayala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cui, X" uniqKey="Cui X">X. Cui</name></author><author><name sortKey="Wu, R" uniqKey="Wu R">R. Wu</name></author><author><name sortKey="Zhou, M" uniqKey="Zhou M">M. Zhou</name></author><author><name sortKey="Simms, H H" uniqKey="Simms H">H. H. Simms</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rubenfeld, G D" uniqKey="Rubenfeld G">G. D. Rubenfeld</name></author><author><name sortKey="Caldwell, E" uniqKey="Caldwell E">E. Caldwell</name></author><author><name sortKey="Peabody, E" uniqKey="Peabody E">E. Peabody</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rubenfeld, G D" uniqKey="Rubenfeld G">G. D. Rubenfeld</name></author><author><name sortKey="Herridge, M S" uniqKey="Herridge M">M. S. Herridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esbenshade, A M" uniqKey="Esbenshade A">A. M. Esbenshade</name></author><author><name sortKey="Newman, J H" uniqKey="Newman J">J. H. Newman</name></author><author><name sortKey="Lams, P M" uniqKey="Lams P">P. M. Lams</name></author><author><name sortKey="Jolles, H" uniqKey="Jolles H">H. Jolles</name></author><author><name sortKey="Brigham, K L" uniqKey="Brigham K">K. L. Brigham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, G" uniqKey="Muller G">G. Muller</name></author><author><name sortKey="Steinbach, G" uniqKey="Steinbach G">G. Steinbach</name></author><author><name sortKey="Berndt, A" uniqKey="Berndt A">A. Berndt</name></author><author><name sortKey="Kohler, H" uniqKey="Kohler H">H. Kohler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reiss, L K" uniqKey="Reiss L">L. K. Reiss</name></author><author><name sortKey="Uhlig, U" uniqKey="Uhlig U">U. Uhlig</name></author><author><name sortKey="Uhlig, S" uniqKey="Uhlig S">S. Uhlig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Birukov, K G" uniqKey="Birukov K">K. G. Birukov</name></author><author><name sortKey="Zebda, N" uniqKey="Zebda N">N. Zebda</name></author><author><name sortKey="Birukova, A A" uniqKey="Birukova A">A. A. Birukova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, X" uniqKey="Gao X">X. Gao</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name></author><author><name sortKey="Liang, Z" uniqKey="Liang Z">Z. Liang</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, J T" uniqKey="Hu J">J. T. Hu</name></author><author><name sortKey="Lai, J" uniqKey="Lai J">J. Lai</name></author><author><name sortKey="Zhou, W" uniqKey="Zhou W">W. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khatri, M" uniqKey="Khatri M">M. Khatri</name></author><author><name sortKey="Richardson, L A" uniqKey="Richardson L">L. A. Richardson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author><author><name sortKey="Chang, G" uniqKey="Chang G">G. Chang</name></author><author><name sortKey="Huang, J" uniqKey="Huang J">J. Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name></author><author><name sortKey="Yu, X" uniqKey="Yu X">X. Yu</name></author><author><name sortKey="Yu, S" uniqKey="Yu S">S. Yu</name></author><author><name sortKey="Kou, J" uniqKey="Kou J">J. Kou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z. Yang</name></author><author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D. J. Klionsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D. J. Klionsky</name></author><author><name sortKey="Emr, S D" uniqKey="Emr S">S. D. Emr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo, S" uniqKey="Lo S">S. Lo</name></author><author><name sortKey="Yuan, S S F" uniqKey="Yuan S">S.-S. F. Yuan</name></author><author><name sortKey="Hsu, C" uniqKey="Hsu C">C. Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, Y" uniqKey="Hong Y">Y. Hong</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name></author><author><name sortKey="Zhang, J M" uniqKey="Zhang J">J.-M. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fang, Y" uniqKey="Fang Y">Y. Fang</name></author><author><name sortKey="Fu, X J" uniqKey="Fu X">X.-J. Fu</name></author><author><name sortKey="Gu, C" uniqKey="Gu C">C. Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name></author><author><name sortKey="Tao, Y" uniqKey="Tao Y">Y. Tao</name></author><author><name sortKey="Zhang, Z M" uniqKey="Zhang Z">Z.-M. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bai, G" uniqKey="Bai G">G. Bai</name></author><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name></author><author><name sortKey="Ge, Y" uniqKey="Ge Y">Y. Ge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bai, X" uniqKey="Bai X">X. Bai</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author><author><name sortKey="Yuan, L" uniqKey="Yuan L">L. Yuan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, N P" uniqKey="Young N">N. P. Young</name></author><author><name sortKey="Kamireddy, A" uniqKey="Kamireddy A">A. Kamireddy</name></author><author><name sortKey="Van Nostrand, J L" uniqKey="Van Nostrand J">J. L. Van Nostrand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, H" uniqKey="Lu H">H. Lu</name></author><author><name sortKey="Fan, Y" uniqKey="Fan Y">Y. Fan</name></author><author><name sortKey="Qiao, C" uniqKey="Qiao C">C. Qiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pastore, N" uniqKey="Pastore N">N. Pastore</name></author><author><name sortKey="Vainshtein, A" uniqKey="Vainshtein A">A. Vainshtein</name></author><author><name sortKey="Klisch, T J" uniqKey="Klisch T">T. J. Klisch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y. Gao</name></author><author><name sortKey="Gui, Q" uniqKey="Gui Q">Q. Gui</name></author><author><name sortKey="Jin, L" uniqKey="Jin L">L. Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C. Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Wu, Q" uniqKey="Wu Q">Q. Wu</name></author><author><name sortKey="Song, S" uniqKey="Song S">S. Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tao, B" uniqKey="Tao B">B. Tao</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L. Liu</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author><author><name sortKey="Jiang, J" uniqKey="Jiang J">J. Jiang</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Z H" uniqKey="Chen Z">Z. H. Chen</name></author><author><name sortKey="Kim, H P" uniqKey="Kim H">H. P. Kim</name></author><author><name sortKey="Sciurba, F C" uniqKey="Sciurba F">F. C. Sciurba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Csordas, A" uniqKey="Csordas A">A. Csordas</name></author><author><name sortKey="Kreutmayer, S" uniqKey="Kreutmayer S">S. Kreutmayer</name></author><author><name sortKey="Ploner, C" uniqKey="Ploner C">C. Ploner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author><author><name sortKey="Liang, B" uniqKey="Liang B">B. Liang</name></author><author><name sortKey="Shirwany, N A" uniqKey="Shirwany N">N. A. Shirwany</name></author><author><name sortKey="Zou, M H" uniqKey="Zou M">M. H. Zou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z. Zhou</name></author><author><name sortKey="You, Z" uniqKey="You Z">Z. You</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, D" uniqKey="Zhang D">D. Zhang</name></author><author><name sortKey="Li, C" uniqKey="Li C">C. Li</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shintani, T" uniqKey="Shintani T">T. Shintani</name></author><author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D. J. Klionsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glick, D" uniqKey="Glick D">D. Glick</name></author><author><name sortKey="Barth, S" uniqKey="Barth S">S. Barth</name></author><author><name sortKey="Macleod, K F" uniqKey="Macleod K">K. F. Macleod</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, P" uniqKey="Jiang P">P. Jiang</name></author><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N. Mizushima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsieh, C H" uniqKey="Hsieh C">C.-H. Hsieh</name></author><author><name sortKey="Pai, P Y" uniqKey="Pai P">P.-Y. Pai</name></author><author><name sortKey="Hsueh, H W" uniqKey="Hsueh H">H.-W. Hsueh</name></author><author><name sortKey="Yuan, S S" uniqKey="Yuan S">S.-S. Yuan</name></author><author><name sortKey="Hsieh, Y C" uniqKey="Hsieh Y">Y.-C. Hsieh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webb, J L" uniqKey="Webb J">J. L. Webb</name></author><author><name sortKey="Ravikumar, B" uniqKey="Ravikumar B">B. Ravikumar</name></author><author><name sortKey="Rubinsztein, D C" uniqKey="Rubinsztein D">D. C. Rubinsztein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gottlieb, R A" uniqKey="Gottlieb R">R. A. Gottlieb</name></author><author><name sortKey="Mentzer, R M" uniqKey="Mentzer R">R. M. Mentzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, J" uniqKey="Ho J">J. Ho</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J. Yu</name></author><author><name sortKey="Wong, S H" uniqKey="Wong S">S. H. Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, F" uniqKey="Jiang F">F. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Settembre, C" uniqKey="Settembre C">C. Settembre</name></author><author><name sortKey="Di Malta, C" uniqKey="Di Malta C">C. Di Malta</name></author><author><name sortKey="Polito, V A" uniqKey="Polito V">V. A. Polito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sardiello, M" uniqKey="Sardiello M">M. Sardiello</name></author><author><name sortKey="Palmieri, M" uniqKey="Palmieri M">M. Palmieri</name></author><author><name sortKey="Di Ronza, A" uniqKey="Di Ronza A">A. di Ronza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santin, Y" uniqKey="Santin Y">Y. Santin</name></author><author><name sortKey="Sicard, P" uniqKey="Sicard P">P. Sicard</name></author><author><name sortKey="Vigneron, F" uniqKey="Vigneron F">F. Vigneron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Settembre, C" uniqKey="Settembre C">C. Settembre</name></author><author><name sortKey="Ballabio, A" uniqKey="Ballabio A">A. Ballabio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fullgrabe, J" uniqKey="Fullgrabe J">J. Füllgrabe</name></author><author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D. J. Klionsky</name></author><author><name sortKey="Joseph, B" uniqKey="Joseph B">B. Joseph</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Fu, Zhiling" sort="Fu, Zhiling" uniqKey="Fu Z" first="Zhiling" last="Fu">Zhiling Fu</name></noRegion><name sortKey="Wu, Xiuying" sort="Wu, Xiuying" uniqKey="Wu X" first="Xiuying" last="Wu">Xiuying Wu</name><name sortKey="Zhang, Jin" sort="Zhang, Jin" uniqKey="Zhang J" first="Jin" last="Zhang">Jin Zhang</name><name sortKey="Zhang, Ze" sort="Zhang, Ze" uniqKey="Zhang Z" first="Ze" last="Zhang">Ze Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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